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Statistics for Terrified Biologists
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Review
“I recommend the book to students of biological disciplines and to those still hesitating about their understanding of the basics of statistics applied in biological research.” (Photosynthetica, 2011) "The book is a very useful addition to the library of any student, or indeed professional biologist, who has ever had trouble determining what the point was to a statistical analysis, or what the results really mean." (Austral Ecology and Ecological Management & Restoration, 2011) “We highly recommend it—not just for statistically terrified biology students and faculty, but also for those who are occasionally anxious or uncertain. In addition to being a good starting point to learn statistics, it is a useful place to return to refresh your memory.” (The Quarterly Review of Biology, March 2009) "Statistics for Terrified Biologists provides a valuable guide to statistics in clear language, which make it invaluable for pre-health and biology undergraduates students. Highly recommended." (CHOICE, March 2009) "I would like to express my utmost gratitude to you for writing THE book on statistics for biologists. Your book makes statistics tangible and enjoyable. I've begun spreading the word to the other faculty here, and two have already purchased copies for themselves. I thank you for your time, and this gift you have given biology as a whole!" E. Joseph Nolan IV (West Liberty University, November 2011)
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From the Back Cover
The typical biology student is “hardwired” to be wary of any tasks involving the application of mathematics and statistical analyses, but the plain fact is much of biology requires interpretation of experimental data through the use of statistical methods. This unique textbook aims to demystify statistical formulae for the average biology student. Written in a lively and engaging style, Statistics for Terrified Biologists draws on the author’s 30 years of lecturing experience. One of the foremost entomologists of his generation, van Emden has an extensive track record for successfully teaching statistical methods to even the most guarded of biology students. For the first time basic methods are presented using straightforward, jargon-free language. Students are taught to use simple formulae accurately to interpret what is being measured with each test and statistic, while at the same time learning to recognize overall patterns and guiding principles. Complemented by simple illustrations and useful case studies, this is an ideal statistics resource tool for undergraduate biology and environmental science students who lack confidence in their mathematical abilities.
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Product details
Paperback: 360 pages
Publisher: Wiley-Blackwell; 1 edition (April 28, 2008)
Language: English
ISBN-10: 1405149566
ISBN-13: 978-1405149563
Product Dimensions:
6.2 x 0.7 x 9.3 inches
Shipping Weight: 1.2 pounds (View shipping rates and policies)
Average Customer Review:
3.6 out of 5 stars
18 customer reviews
Amazon Best Sellers Rank:
#452,753 in Books (See Top 100 in Books)
To give background, I took AP Statistics in high school and a more advanced statistics course in college. I bought this book as a refresher for some biostatistics research that I needed to do. Bad decision. The author needlessly complicates simple concepts by taking a paternalistic stance over the reader: "you're probably terrified by symbols, so let me mansplain statistics to you in a trite, disorganized, borderline-cutesy way." The author tries to reinvent the wheel in order to avoid the use of algebra, needlessly substituting symbols with silly nicknames and elegant mathematical summaries with rambling paragraphs. Most irritatingly, the author cannot write -- concision, organization, and clarity go out the window in this awful, error-ridden excuse for an educational text.If you already have a statistics background, I would absolutely NOT recommend this book. It's cheesy, it's poorly written (so!! many!! unnecessary!! exclamation!! points!!!!!!!!!!!!!), and so utterly inefficient as a review that I felt the need to open up the product page and spend fifteen minutes punching out this warning to potential buyers.
This book absolutely saved my life. I HIGHLY recommend it. I am a graduate student and wish I would have known about it during my undergrad! It reads more like a novel than a textbook, which helped me immensely. For anyone looking to have stats explained to you like you're having a conversation with a very intelligent, but very relatable friend, this book is for you!
It is loaded with formulas. Speaking as a biologist, that is a terrifying sight. I sort of expected a more verbal description, funny, friendly, like Robert A. Day's Scientific English which is really great. So I'm back to begging for help from our statisticians. Hope springs eternal that someone, someday, will write a statistics book for scientists.
Oh, man. I am not a fan of stats. Needed for a class. It is a good book though. Teaches hard to understand concepts in a understandable. way.
The book is written so as to understand and respond to questions we biologists rarely get from people in the field of statistics, especialy agronomists. I am a plant physiology researcher and many times I felt terrified to cope properly with the statistical standards of the college of agriculture and my biological point of view and results. Eventhough I have the basis for staistical analyses, at times I had to accept that the biological point of view didnot met the statistical standards. Now I am not confused anymore as differences are clear to me after studying the book thus I recommend the book as a very clarifiying guide to the experimenter specially in the biological sciences.
This is one of my go to references when I am running analysis or planning an experiment. I have always been really bad at remembering the tiny details in statistics, this book presents them in a way that is intuitive and easy to understand. Better yet it has deepened my understanding of some core concepts that let me choose the right statistical model and given me the tools to argue for why I chose that particular model. I would highly recommend as a desktop reference.
Very easy to follow and explains everything in a way that I can understand. It actually brings a great deal of fun and satisfaction to read and work through the text. I would recommend this to anyone who wants to really get their head around the inner workings of experimental design and agricultural based statistics.
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Get Free Ebook Gravity, by Jason Chin
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Gravity, by Jason Chin
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From School Library Journal
Gr 2–5—How do we stay put on our planet and not float away into outer space? What makes things fall to the ground from high places? Chin introduces youngsters to the concept of gravity, presenting the information in highly understandable language and in captivating paintings that will delight young readers. Deceptively simple large print text describe how gravity affects all things on Earth as well as in outer space. Colorful and incredibly detailed watercolor landscapes and close-up illustrations keep readers' attention, and certain objects are repeated throughout the pages. Although Gravity is set up like a fictional text, the information necessary to understand the basics of gravity are present. This is a wonderful addition to libraries for younger students. In the "More About Gravity" section, readers can add to their increasing knowledge of the topic with important vocabulary and comparisons that allow for deeper understanding.—Katy Charles, Virgil Elementary School, Cortland, NY
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From Booklist
A book on gravity falls onto a beach where a boy is playing with his toy astronaut and spaceship. Suddenly “without gravity,†everything (except the boy, who clutches an outcropping of rock) starts rising into the air and floating off into space. In the end, because “everything has gravity,†the objects fall back to earth, but the boy’s possessions end up at a lemonade stand, while a pitcher of lemonade and cups land near him. As in Chin’s Redwoods (2009) and Coral Reefs (2011), an informational text is paired with imaginative and often striking illustrations. But here, the text is quite brief, and the term gravity is explained only in the appended notes. While the main section of the book illustrates a lack of gravity in memorable ways, it does little to make the concept of gravitational pull more understandable to children. Teachers will find Franklin Branley’s Gravity Is a Mystery (2007) more useful, but Chin’s picture book will be an attractive addition to classroom units. A visually impressive piece of storytelling, it will please kids who enjoy what-if scenarios. Grades K-3. --Carolyn Phelan
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Product details
Age Range: 5 - 8 years
Grade Level: 1 - 2
Hardcover: 32 pages
Publisher: Roaring Brook Press (April 29, 2014)
Language: English
ISBN-10: 1596437170
ISBN-13: 978-1596437173
Product Dimensions:
11.3 x 0.4 x 8.8 inches
Shipping Weight: 12.8 ounces (View shipping rates and policies)
Average Customer Review:
4.6 out of 5 stars
26 customer reviews
Amazon Best Sellers Rank:
#158,274 in Books (See Top 100 in Books)
We borrowed this book from our local library and my child loved it. So, for Christmas, we bought him the book, and he was SO happy! :) The words aren't too complicated, but introduce some scientific principles in an interesting and fun way.
simple, but effective text is supported by vivid illustration in this concept book. The sparse wording is clear and effective at teaching the concept without being weighed down by verbosity. excellent choice.
Five stars for this beautiful book. Fun for kids. Also recommend his first book "Redwoods," which is a great introduction to nature for kids.
Good book. Children loved it
Great for teaching young children the concept of "gravity." My 4 year-old niece got the concept immediately.
Beautiful illustrations. Excellent condition. Came when promised. I enjoyed reading it with my students.
Very good condition. Was very pleased with this purchase.
Amazing book! So educational. Gorgeous illustrations.
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Product details
File Size: 3811 KB
Print Length: 100 pages
Simultaneous Device Usage: Unlimited
Publisher: O'Reilly Media; 1 edition (August 27, 2012)
Publication Date: August 27, 2012
Sold by: Amazon Digital Services LLC
Language: English
ASIN: B0092UB21U
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This book was a pretty good overview of things to keep track of when trying to maintain accessibility to websites to those with some kind of disability. I'm a human factors person, so the codes provided really didn't mean much to me, but the concepts and heuristics behind them are valuable for anyone. I would argue that all these suggestions would be valuable for designing an off-line interface just as well as for a web interface. The author even provides a list of tools that the reader can use and where to find them, though a couple of the hyperlinks might not be applicable anymore. I would have like to have gotten a little more background on cascading style sheets and how they are actually implemented, but it might have just been beyond the scope of the book. Overall, a solid little piece of work to keep in the library.
Great overview of web accessibility. Would definitely recommend to anyone starting out in web design/development looking for a way to start making their site accessible to everyone. It's such an important thing that people need to stop looking over when developing websites.
So poorly written that it is not readable, I have lost some of my accessibility knowledge trying to understand what he wrote.
The Accessibility Handbook is written for people who code web sites. It will identify the conditions, both physical and cognitive, that require special coding accommodation and provide sample code and guidance on how to gain compliance with section 508 of the U.S. Rehabilitation Act. Compliance is required for all Federal Agencies and contractors. It is also a standard followed by many state and local governments and has served as a basis for other countries implementing accessibility standards. The author defines several conditions that can limit a user in their ability to use a website. Code samples demonstrate techniques for overcoming the challenges some users face. Major topics include users with complete blindness, low vision, audio limitations, physical limitations, and cognitive disorders. The book contains links to other resources and tools useful in coding an accessible website. I tested several and found areas that I can improve. On thing to consider is the number of older users that may need to increase type to view the site easily. This would fall under a low vision condition. I find myself using CRTL+ + to increase font sizes quite often. We give much consideration to making responsive designs to accommodate different devices. How often do we consider the user that has to increase font sizes greatly to read the type? Have we considered how that awesome drop down menu affects a person that must navigate with the keyboard or a screen reader? These are type of issues that would fall under accessibility. I liked this book and would highly recommend it. I learned about website use factors that I had previously never considered. I knew color blindness existed. I did not know there were different types and how things might appear to someone with the condition. I have often used color to indicate a current page in a navigation menu. This is a practice I will alter in future designs. My intention is to make accessibility a prime consideration in my designs. This will aid users with challenges and provide a better website for all. Disclosure: I recieved a free e-book copy for review purposes.
Katie Cunningham's "Accessibility Handbook" (O'Reilly, 2012) is a concise and specific introduction to accessibility (a11y) and 508-compliance. Cunningham provides a "walking tour" of the major types of disabilities that web developers need to consider when creating a site for a11y, illustrating how people with those disabilities will use a site, and then detailing easy solutions and best practices to craft a site with the necessary accommodations. Better yet, she makes strong cases for why many of these accommodations are actually "features" and not "compromises".The book is broken into chapters such that each one focuses on a specific disability. Some of these disabilities may seem obvious (e.g., blindness, deafness), while others may come as a surprise (e.g., color blindess, motion disorders). Having the book sectioned in this way was a smart choice, as it becomes easy to focus on that one type of disability, and to reason about the strategies necessary for accommodating it. The goal of each chapter is to get you (as a developer) into a headspace where you can easily understand how a person with one of those disabilities will approach your site, thus making it easier for you to understand the 508-compliance rules.As a front-end developer without much experience in the realm of a11y, and with no knowledge of 508-compliance, I approached this book as a good place to start. Having finished it, I maintain that it was a good introduction to the subject. Though I got the information about the disabilities and how to accommodate them, there was almost nothing in here about WAI-ARIA--granted: Cunningham cites ARIA, and shows some examples when talking about "Complete Blindness", but she also says that it's too big of a subject to cover in her book. That being said, when I find a good resource on ARIA, I'll be pleased to know that this book gave me a decent framework for thinking about those problems.Lastly, as I mentioned before, Cunningham does a decent job of explaining why many of the accommodations that she describes actually become "features" of your site, and not "compromises". For example: everyone can benefit from having good `tabindex` properties set your form fields. For example: everyone benefits from well-labeled graphs and charts. For example: by making your menus, icons, and other click-targets "adequately sized", you're not only helping someone with Parkinsons, you're also helping people accessing your site from a mobile device. And lastly, my favorite example: by paying attention to the source order of the elements in your site, you're not only helping the blind (and/or anyone else using a screen reader) but you're also making it easier to give your site a responsive design (and I hear it's helpful for SEO, as well).Would I recommend this book? Yes, to someone who needs a quick "walking tour" of a11y--but probably not to someone who is already familiar with the subject, and definitely not to someone who is looking for more on WAI-ARIA.Full disclosure: I received an electronic copy from the publisher in exchange for writing a review.
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Ebook Download ASE Test Preparation - P2 Parts Specialist (Delmar Learning's Test Preparation)
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ASE Test Preparation - P2 Parts Specialist (Delmar Learning's Test Preparation)
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About the Author
Find learning solutions to boost your career, augment your curriculum, improve your training courses or help you master new skills, from the leader in skills based solutions for educational institutions, businesses, and professionals - Delmar, a part of Cengage Learning.
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Product details
Series: Delmar Learning's Test Preparation
Paperback: 224 pages
Publisher: Cengage Learning; 5 edition (February 3, 2012)
Language: English
ISBN-10: 111112714X
ISBN-13: 978-1111127145
Product Dimensions:
8.5 x 0.8 x 10.9 inches
Shipping Weight: 1.6 pounds (View shipping rates and policies)
Average Customer Review:
4.4 out of 5 stars
42 customer reviews
Amazon Best Sellers Rank:
#276,388 in Books (See Top 100 in Books)
This book, along with some free materials provided by my place of employment, prepared me to pass my P2 exam within a short period of time. The book is plenty well thought out and easy to read, and has good diagrams. There are multiple errors in the practice exam though, so it gets docked one star for that due to me being confused a couple of times.An example of this: Question: Something easy that you KNOW the answer to...Answer A would state INCORRECT (even thoough you know it is correct) and then it explains why it IS correct? What?Answer B Correct (which would be way wrong) stating why it is way wrong.Answer C Incorrect and why its incorrectAnswer D Incorrect and why its incorrect.This confused me the first couple of times until I realize what to look for. This could definitely be improved.
I studied this prep book and it worked out very well for me! I am certified now and passed the proctored exam with near perfection!If you do study this program, read it thru a couple of times, then test yourself! Do the tests over again to be SURE you've got it down pat!
Way way better than the competitor's prep manual. Still, I've been using this in the parts program I teach at a local college and there are a bunch of errors in the test answers. Someone really needs to edit these things that is familiar with the subjects.
Found this book to be very helpful. Studied it thoroughly and passed with ease. Now waiting for the P1 to become available.
The first time I took the P2 test,I didn't use study material and I failed it by one point.I bought this book and on my second attempt I passed by one point.I think more than anything this book gives you the philosophy behind the answers.It's one thing to understand you answered a question incorrectly yet an entirely different world when you ask WHY you answered incorrectly and that is the beginning of stacking the odds in your favor.The practice test will help you learn your weak areas and shore up those areas with explanations for the correct answer followed by footnotes to the tasks that further explain the reasoning for the correct answer.However keep in mind that the practice test is not the actual test because there are many versions of it. ASE goes through too much trouble to keep the integrity of the test at a certification level. Good luck and God bless
I studied for the test using this book and all the tests within it and passed.
This series is great for studying for the ASE or for review period. I really like the way it presents the material to lear and the combination with the questions.
Was helpful.....helps get you used to the trick questions they ask
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File Size: 2286 KB
Print Length: 447 pages
Publisher: Middleway Press (August 1, 2013)
Publication Date: August 1, 2013
Language: English
ASIN: B00EN8N8TU
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Amazon Best Sellers Rank:
#785,652 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
This text is highly engaging, motivating, and drives the spirit. As a 28 year old who teaches adolescents, it made me realize how much I need to grow up. I am part of a demographic that encompasses the concept of 20teen. Though this book promotes youth, it is important to live as an adult while maintaining a young spirit.
One of the best books I've read.
Outstanding
Must read item for all the youth.
This book might give helpful encouraging advise but I learned the hard way that the soka gakki is really a cult and I wanted to warn people so that they don't get hurt by it like me.
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Download Ebook Let's Visit Vancouver!: Adventures of Bella & Harry, by Lisa Manzione
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Let's Visit Vancouver!: Adventures of Bella & Harry, by Lisa Manzione
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From the Author
The series was developed with the hope of inspiring young readers to embrace the world and encourage its exploration. Done through the comedic and informative adventures of Bella and Harry, while traveling through various countries, I hope to stimulate children's imaginations and foster a thirst for understanding the world in which they live.
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About the Author
The Bella and Harry series of children's books is Lisa Manzione's first foray into children's fiction writing. As a member of the Society of Children's Book Writers and Illustrators (SCBWI), Lisa's entrance into the field of literature is one she has eagerly awaited and is very passionate about. As the daughter of a single parent who worked for a major airline, Lisa's exposure to (and interest in) travel began at an early age. Later in life, as Lisa's own children grew up and her love of animals continued, the idea for the Bella and Harry series was born. Author Lisa Manzione resides in Delray Beach, FL Born in rural Pennsylvania, Kristine's passion for art began at a young age. This interest in art continued and ultimately led Kristine to study at the Art Institute of Fort Lauderdale. Now a mother of two avid junior readers, Kristine’s unique talent and particular flair for children’s themes has evolved quite naturally into the world of children’s books and illustrations. She is quick to credit her own children for inspiring this phase of her art, as it is often conceived by seeing the characters and places through their eyes. In addition to her work on the Bella and Harry series, Kristine has also illustrated the most recently recognized children’s book, “Wacky Jacky, The True Story of an Unlikely Beauty Queenâ€. Illustrator Kristine Lucco resides in Boca Raton, FL
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Product details
Age Range: 5 - 10 years
Grade Level: Kindergarten - 3
Lexile Measure: 590L (What's this?)
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Series: Adventures of Bella & Harry (Book 14)
Hardcover: 35 pages
Publisher: Bella & Harry (October 1, 2014)
Language: English
ISBN-10: 1937616541
ISBN-13: 978-1937616540
Product Dimensions:
8.5 x 0.5 x 10.8 inches
Shipping Weight: 12 ounces (View shipping rates and policies)
Average Customer Review:
5.0 out of 5 stars
4 customer reviews
Amazon Best Sellers Rank:
#816,926 in Books (See Top 100 in Books)
With family in Vancouver, 'Good Night Vancouver' has been a household staple for us for awhile. Bella & Harry is a nice next step for older kids and includes a good amount of area education. Our kids loved reading about places, seeing them and then reading about them again. One slight concern with this book is it does highlight a number of expensive activities that readers are likely to ask to do; i.e., visiting/snowboarding on Grouse Mtn, a whale watch, and Capilano Park are all big ticket items for visitors to BC.
Great book.
Ny grandson loves it.
A great way to teach children about another country!
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Download Macrocycles in Drug Discovery
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Macrocycles in Drug Discovery
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Review
"The book is a wellmade snapshot of current research, describing development stories of established macrocycle drugs and their properties, as well as new avenues in their development." "The book s 11 chapters, written by distinguished experts, are mostly dedicated to macrocycles for a specific protein target or target class." "Numerous examples presented along with the compounds potency, selectivity, permeability, bioavailability and other properties allow the reader to understand which determinants make a successful macrocyclic drug."--Christian Heinis "Chemistry World """"Macrocycles in Drug Discovery" provides an in-depth review with case studies of some of the major targets and areas that have been the focus of macro- cyclic drug discovery. It also provides useful insights into macrocycle cell permeability, oral bioavailability and methods for their synthesis." " rich in information " "I absolutely recommend "Macrocycles in Drug Discovery" to those that are active in the field, both in academia and the pharmaceutical industry. The different chapters provide stimulating reading for experts in macrocycles as well as for organic chemists and medicinal chemists in general. The comprehensive chapters also serve as a source of references with extensive citation of the primary literature."--Prof. Jan Kihlberg "Chemmedchem review in March 2015 issue ""Macrocycles are usually defined as having a structure that includes a ring of 12 or more heavy atoms. They are an interesting class of small molecules that have found wide use as antibiotics, as therapeutic agents in oncology, and for immunosuppression, but also across a large number of other indications. Many macrocyclic drugs are natural products that were isolated and discovered prior to the emergence of target- based drug discovery and high-through- put screening. Despite this precedent, macrocycles were largely out of focus in drug discovery research for a number of years. Interest in macrocycles has undergone a major revival over the past decade for several reasons. It has been argued that too strict an implementation of the Lipinski s rule of five (Ro5) has hampered the pharmaceutical industry from seizing opportunities involving novel but difficult targets. This has put the spotlight on compounds outside the Ro5 as tool agents in chemical biology and as leads for drug discovery. Macrocycles are of particular prominence in this space as they have been hypothesized to be better suited to modulate difficult targets with large and flat binding sites be- cause of their size, shape and flexibility. In addition, a number of natural-product-based and designed macrocycles are also cell permeable and orally bioavailable, making them of particular interest among the drugs outside the Ro5 guide- lines. "Macrocycles in Drug Discovery" provides an in-depth review with case studies of some of the major targets and areas that have been the focus of macro- cyclic drug discovery. It also provides useful insights into macrocycle cell permeability, oral bioavailability and methods for their synthesis. As Nature is the main source of macrocyclic drugs, it is appropriate that Chapter 1 of the book provides an overview of different classes of macrocyclic natural products. This ranges from sources of isolation and bio- synthesis, via synthetic approaches, to pharmacological activities and clinical applications. Chapter 1, as all chapters in the book, is rich in information and therefore not bedside reading unless you are an expert in the field. In general, Chapters 2 7 review and discuss how macrocycles have been dis- covered and developed to modulate different targets of interest for the treatment of disease. Each chapter starts with an introduction to the field to whet the appetite of the reader, followed by a systematic overview of data and insights gathered, such as for different classes of macrocycles. These chapters also provide important lessons from historical macro- cycle drug discovery. Thus, macrocycles that target heat shock protein 90 (Hsp90), epothilones as stabilizers of microtubules, inhibitors of zinc-dependent histone deacetylases (HDACs) and macrocyclic kinase inhibitors, which are all used in oncology, are reviewed in Chapters 2 5. Chapters 6 and 7 discuss the use of anti-inflammatory macrolides to manage chronic neutrophilic inflammation and the recent discoveries of hepatitis C virus protease inhibitors. Chapter 8 provides an impressive overview of how cyclic mimetics of protein epitopes have been developed to target G-protein-coupled receptors (GPCRs), integrins and protein protein interactions (PPIs). In line with this theme, Chapter 9 is focused on macrocyclic a-helical peptides, in particular stapled peptides and their use to inhibit PPIs. Last but not least, Chapters 10 and 11 provide general and extensive overviews of properties that influence cell permeability and oral bioavailability of macrocycles, as well as methods for their synthesis, respectively. Chapter 10 has a particularly interesting introductory section on modelling of permeability and absorption. This is followed by a brief overview of oral bioavailability of macrocycles, which can be supplemented from citations throughout the book, particularly those in the introduction of Chapter 1. Chapter 11 provides a very extensive review of how macrocycles have been synthesized (434 references), but is easy to access from its systematic organization by the methodology used for the macrocyclization step. In particular, the section on how macrocyclizations have been scaled up in process chemistry departments illustrates how far chemistry has progressed in this field during recent years. Additional reading to this section should include the use of diversity- oriented synthesis (DOS) to generate synthetic libraries of macrocycles for drug discovery. All books will have some drawbacks and omissions; a few minor ones have been alluded to above in the overview of the different chapters. Additional topics that readers should be aware of include cyclosporine A for which substantial studies have been undertaken to explain how it crosses cell membranes. These studies form a historical basis for which current research aimed at identifying strategies for design of cell-permeable cyclic peptides are based. Chapter 9 on stapled peptides is written with a very optimistic viewpoint that differs somewhat from current discussions in the primary literature, as well as the more stringent tone of the other chapters. It would have benefitted from a more extensive discussion of cell penetration of macrocyclic a-helical peptides. As written, the reader is left with the understanding that stapled peptides rely on active transport processes to enter cells, where they then elicit their pharmacological effect. However, a discussion of the current research on whether these transport processes allow general and re- producible drug delivery to a diverse population of patients is lacking. Another lingering question is whether or not there are limitations to whether stapled peptides reach their destinations inside the cell after active uptake. In spite of the minor concerns indicated above, I absolutely recommend "Macrocycles in Drug Discovery" to those that are active in the field, both in academia and the pharmaceutical industry. The different chapters provide stimulating reading for experts in macrocycles as well as for organic chemists and medicinal chemists in general. The comprehensive chapters also serve as a source of references with extensive citation of the primary literature. In addition, the chapters are well organized, and it is therefore easy to locate the reader s particular topic of interest. However, "Macrocycles in Drug Discovery" is best red one chapter at a time, not from cover to cover, due to the vast amount of information it summarizes. Each reader that has taken the time to carefully read through this book will be better positioned for retrospective analysis of macrocyclic drug discovery and speculation on what the future may look like.--Prof. Jan Kihlberg, Uppsala University (Sweden) "Chemmedchem review in March 2015 issue ""Macrocycles are ring-shaped molecules containing12 or more ring atoms. Many important drugs belong to this structural class, for example the immunosuppressant cyclosporine or the antibiotic vancomycin. Macrocycles' ability to bind difficult targets that are considered 'undruggable' by traditional small molecule drugs has produced much interest. Recent innovations for designing de novo macrocycles and for screening large combinatorial macrocycle libraries have given an additional impulse to the field's development. The book is a well-made snapshot of current research, describing development stories of established macrocycle drugs and their properties, as well as new avenues in their development. The book's 11chapters, written by distinguished experts, are mostly dedicated to macrocycles for a specific protein target or target class. The targets discussed include heat shock protein, tubulin, histone deacetylases, kinases, proteases, G-protein coupled receptors, integrins, and protein protein interactions. Several authors provide introductory sections about the general characteristics of macrocycles, meaning that there is a small overlap between some chapters. However, this is not negative at all as it offers different perspectives on the topic. Most established macrocyclic drugs are based on natural products that were identified in bacteria, fungi, plants or other organisms. Consequently, the majority of molecules discussed are natural products or derivatives thereof. As nature does not offer macrocycles for every therapeutic target, scientists have designed new macrocycles, which are also covered in the book. Chapters are dedicated to the design of kinase inhibitors and to intriguing strategies for developing macrocycles de novo by mimicking protein epitopes such as hairpins or helices. To develop novel macrocycles, it is essential to understand the factors that affect their permeability and bioavailability-important topics that are discussed in the penultimate chapter. The book concludes with a comprehensive chapter on synthetic strategies for the production of macrocycles. In summary, this title is an in depth discussion of macrocycle drug discovery. Numerous examples presented along with the compounds' potency, selectivity, permeability, bioavailability and other properties allow the reader to understand which determinants make a successful macrocyclic drug.--Christian Heinis "Chemistry World ""
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From the Inside Flap
This book reviews macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. The medicinal chemistry of macrocyclic natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, are now informing the design of fully synthetic macrocyclic drug candidates against a variety of targets including kinases, ATPases, proteases, GPCRs and others. Furthermore, as more non-classical drug targets, such as protein–protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are generating increasing interest as they offer a way to provide drug–protein interactions that cover a larger surface area than traditional small molecules.A variety of macrocycles have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds, their pharmacology and synthesis, in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.
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Product details
Series: Drug Discovery (Book 40)
Hardcover: 528 pages
Publisher: Royal Society of Chemistry; 1 edition (October 16, 2014)
Language: English
ISBN-10: 1849737010
ISBN-13: 978-1849737012
Product Dimensions:
6.2 x 1.2 x 9.2 inches
Shipping Weight: 2.1 pounds (View shipping rates and policies)
Average Customer Review:
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Amazon Best Sellers Rank:
#4,899,451 in Books (See Top 100 in Books)
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